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Biomark Med. 2007 Aug;1(2):319-33. doi: 10.2217/17520363.1.2.319.

From the bench to the clinic and back again: translational biomarker discovery using in silico mining of pharmacogenomic data.

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Gene Logic Inc., 50 West Watkins Mill Road, Gaithersburg, MA 20878, USA.


To improve drug efficacy and safety and advance medical intervention in diseases, new biomarkers are urgently needed. Pharmacogenomics can provide a tool to discover and begin to qualify biomarkers useful for these indications and is readily applicable to multiple species. One can begin and end with genes or focus on tissue-derived expression analysis of those genes that encode secreted proteins to discover potential biomarkers that can be monitored in body fluids. The paper will discuss issues surrounding such investigations, show examples of translational biomarkers and end with a summary of the US FDA's work in this field over the last 6 years.

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