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Curr Top Microbiol Immunol. 2010;347:263-78. doi: 10.1007/82_2010_44.

Small molecule inhibitors of the PI3-kinase family.

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1
The Rockefeller University, New York, NY10065, USA. zknight@rockefeller.edu

Abstract

The PI3-K family is one of the most intensely pursued classes of drug targets. This chapter reviews some of the chemical and structural features that determine the selectivity of PI3-K inhibitors, by focusing on a few key compounds that have been instrumental in guiding our understanding of how to design drugs against this family.

PMID:
20473788
DOI:
10.1007/82_2010_44
[Indexed for MEDLINE]
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