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Inflamm Res. 2010 Nov;59(11):971-8. doi: 10.1007/s00011-010-0211-7. Epub 2010 May 15.

Inflammatory responses improve with milk ribonuclease-enriched lactoferrin supplementation in postmenopausal women.

Author information

1
N-terminus Research Laboratory, Pomona, CA 91768, USA.

Abstract

OBJECTIVE AND DESIGN:

A 6-month, randomized clinical study was conducted to evaluate the effect of a ribonuclease-enriched lactoferrin (R-ELF) supplement on the circulating cytokine levels and bone health of postmenopausal women.

SUBJECTS:

Thirty-eight healthy postmenopausal women, aged 45-60 years, were randomized into placebo and R-ELF groups.

TREATMENT:

The R-ELF group was supplemented with R-ELF (2 × 125 mg/day) and calcium (100% RDA), while the placebo group received only the calcium supplement.

METHODS:

Serum levels of receptor activator for NF-κB ligand (RANKL), C-reactive protein (CRP) and various pro- and anti-inflammatory cytokines were determined by ELISA.

RESULTS:

Pro-inflammatory cytokines IL-6 and TNF-α decreased significantly (-44 and -10%, respectively) while anti-inflammatory IL-10 increased (140%) due to R-ELF supplementation at the end of study. RANKL and CRP were modestly reduced (-50%) relative to their placebo levels, although RANKL elevated initially.

CONCLUSIONS:

R-ELF supplementation showed beneficial effects towards improvement of inflammatory status in postmenopausal women.

PMID:
20473630
DOI:
10.1007/s00011-010-0211-7
[Indexed for MEDLINE]

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