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Behav Brain Res. 2010 Dec 1;213(2):323-7. doi: 10.1016/j.bbr.2010.05.008. Epub 2010 May 20.

The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss.

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1
Psychology Department, University of Otago, Dunedin, New Zealand.

Abstract

The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.

PMID:
20471999
DOI:
10.1016/j.bbr.2010.05.008
[Indexed for MEDLINE]

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