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Mol Cell. 2010 May 14;38(3):323-32. doi: 10.1016/j.molcel.2010.03.013.

Posttranscriptional regulation of microRNA biogenesis in animals.

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1
Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. awa403@sc.itc.keio.ac.jp

Abstract

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.

PMID:
20471939
DOI:
10.1016/j.molcel.2010.03.013
[Indexed for MEDLINE]
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