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Bioorg Med Chem Lett. 2010 Jun 15;20(12):3713-6. doi: 10.1016/j.bmcl.2010.04.085. Epub 2010 Apr 24.

The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists.

Author information

1
Department of Chemistry, Schering-Plough Research Institute, Newhouse, Lanarkshire, UK. mark.reid@spcorp.com

Abstract

Antagonists of the 5-HT(6) receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer's disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides-a novel chemotype of 5-HT(6) antagonists.

PMID:
20471831
DOI:
10.1016/j.bmcl.2010.04.085
[Indexed for MEDLINE]

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