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Biochim Biophys Acta. 2010 Aug;1804(8):1684-9. doi: 10.1016/j.bbapap.2010.05.002. Epub 2010 May 13.

SIRT1 and p53, effect on cancer, senescence and beyond.

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1
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

Abstract

NAD(+)-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically involved in stress responses, cellular metabolism and aging through deacetylating a variety of substrates including p53, forkhead-box transcription factors, PGC-1alpha, NF-kappaB, Ku70 and histones. The first discovered non-histone target of SIRT1, p53, is suggested to play a central role in SIRT1-mediated functions in tumorigenesis and senescence. SIRT1 was originally considered to be a potential tumor promoter since it negatively regulates the tumor suppressor p53 and other tumor suppressors. There is new evidence that SIRT1 acts as a tumor suppressor based on its role in negatively regulating beta-catenin and survivin. This review provides an overview of current knowledge of SIRT1-p53 signaling and controversies regarding the functions of SIRT1 in tumorigenesis.

PMID:
20471503
PMCID:
PMC2989880
DOI:
10.1016/j.bbapap.2010.05.002
[Indexed for MEDLINE]
Free PMC Article
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