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Cell Signal. 2010 Dec;22(12):1799-803. doi: 10.1016/j.cellsig.2010.05.007. Epub 2010 May 12.

Molecular basis of lysophosphatidic acid-induced NF-κB activation.

Author information

1
Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza-BCM320, 6621 Fannin St., MC 3-3320, Houston, TX 77030, United States

Abstract

PKC, β-arrestin 2, CARMA3, BCL10, MALT1, TRAF6 and MEKK3 are signaling proteins that have a key role in G protein-coupled receptor (GPCR)-mediated activation of nuclear factor-κB (NF-κB) pathway in nonhematopoietic cells in response to lysophosphatidic acid (LPA) stimulation. The PKC, β-arrestin 2, CARMA3-BCL10-MALT1-TRAF6 signalosome, and MEKK3 functions as a link between GPCR signaling and IKK-NF-κB activation. Here we briefly summarize recent progress in the understanding of the molecular and biological functions of these proteins in GPCR-mediated NF-κB activation in nonhematopoietic cells.

PMID:
20471472
PMCID:
PMC2939192
DOI:
10.1016/j.cellsig.2010.05.007
[Indexed for MEDLINE]
Free PMC Article

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