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Mol Biochem Parasitol. 2010 Oct;173(2):64-8. doi: 10.1016/j.molbiopara.2010.05.005. Epub 2010 May 13.

Characterization of a novel tyramine-gated chloride channel from Haemonchus contortus.

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  • 1University of Ontario Institute of Technology, Faculty of Science, 2000 Simcoe Street North, Oshawa, ON, L1H 7K4 Canada.


Tyramine (TA), a trace amine, is becoming accepted as a main stream neurotransmitter in invertebrates. Recent evidence indicates that part of the function of TA in nematodes involves a novel receptor (Cel-LGC-55) from the ligand-gated chloride channel class of ionotropic receptors. However, the role of TA or its receptors in the biology of nematode parasites is limited. Haemonchus contortus is a deadly parasitic worm which causes significant economic burden in the production of small ruminants in many parts of the world. In this study, we have cloned and characterized a novel LGCC from H. contortus which we have named Hco-LGC-55. This receptor subunit is a clear orthologue of Cel-LGC-55 and is able to form a homomeric chloride channel that is gated by tyramine, dopamine and octopamine. Semi-quantitative reverse transcription-polymerase chain reaction (sqRT-PCR) shows that this subunit is expressed in all life-cycle stages of the worm, but appears to have reduced mRNA expression in the adult male.

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