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FEBS Lett. 2010 Jul 2;584(13):2896-900. doi: 10.1016/j.febslet.2010.05.008. Epub 2010 May 13.

A lipocalin sequence signature modulates cell survival.

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1
Laboratory of Biochemistry and Biophysics, Butantan Institute, São Paulo, SP, Brazil. amchudzinski@butantan.gov.br

Abstract

Lipocalins are beta-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs (motif 2) that modulates cell survival. A synthetic peptide based on an insect lipocalin displayed cytoprotective activity in serum-deprived endothelial cells and leucocytes. This activity was dependent on nitric oxide synthase. This sequence was found within several lipocalins, including apolipoprotein D, retinol binding protein, lipocalin-type prostaglandin D synthase, and many unknown proteins, suggesting that it is a sequence signature and a lipocalin conserved property.

PMID:
20471382
DOI:
10.1016/j.febslet.2010.05.008
[Indexed for MEDLINE]
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