Obstructive chronic pancreatitis was reproduced in canine model, with the subsequent laser tunneling of pancreas tissue. It was shown, that in the zone of sclerotic changes in pancreas, laser irradiation caused hyperplasia and hypertrophy of acinous cells, augmentation of blood vessels and excretory channels numbers in the reference area, decrease of volume fraction of fibrous tissue that promotes augmentation of pancreas parenchyma.