This article presents a literature review of side effects of antihelikobakter therapy, as well as survey data, whose goal was to determine the efficacy and safety of normoflorins at patients after eradication therapy of peptic ulcer. It was shown that the frequency of occurrence of side effects during antihelikobakter therapy varies widely and can reach, according to different authors, from 30 to 50% of patients. In addition to allergic and toxic PE, with antibacterial agents allocate their influence on the microflora of the colon, which often leads to development of a scarce and dysbacteriosis of antibioticassociated colitis. Appointment of biodiesel of normoflorin after eradication therapy effectively suppresses clinical signs of dyspepsia as a side effect of antihelikobakter therapy enhances the effectiveness of treatment of patients and improve their quality of life.