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Curr Opin Cell Biol. 2010 Jun;22(3):305-13. doi: 10.1016/j.ceb.2010.04.005. Epub 2010 May 11.

3D shortcuts to gene regulation.

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1
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Recent technologies have allowed high-resolution genome-wide binding profiles of numerous transcription factors and other proteins. A widespread observation has emerged from studies in diverse mammalian systems: most binding events are located at great distances from gene promoters. It is becoming apparent that the traditional one-dimensional view of gene regulation via the proximal cis regulatory elements is over-simplified. True proximity and functional relevance can be revealed by studying the three-dimensional structure of the genome packaged inside the nucleus. Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field.

PMID:
20466532
PMCID:
PMC2916936
DOI:
10.1016/j.ceb.2010.04.005
[Indexed for MEDLINE]
Free PMC Article
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