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Curr Opin Cell Biol. 2010 Aug;22(4):461-70. doi: 10.1016/j.ceb.2010.04.007. Epub 2010 May 11.

Rab GEFs and GAPs.

Author information

1
University of Liverpool, Cancer Research Centre, 200 London Road, Liverpool L3 9TA, UK. fabarr@liverpool.ac.uk

Abstract

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.

PMID:
20466531
PMCID:
PMC2929657
DOI:
10.1016/j.ceb.2010.04.007
[Indexed for MEDLINE]
Free PMC Article

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