Send to

Choose Destination
FEBS Lett. 2010 Jul 2;584(13):2883-90. doi: 10.1016/j.febslet.2010.05.004. Epub 2010 May 11.

Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6).

Author information

Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.


Adenylyl cyclase (AC) type VI (AC6) is a calcium-inhibitable enzyme which produces cAMP upon stimulation. Herein, we characterized the specific role of AC6 in the kidneys using two AC6-knockout mouse lines. Immunohistochemical staining revealed that AC6 exists in the tubular parts of the nephron and collecting duct. Activities of AC evoked by forskolin or a selective agonist of the V2 vasopressin receptor were lower in the kidneys of AC6-null mice compared to those of wildtype mice. Results of a metabolic cage assay and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) showed for the first time that AC6 plays a critical role in regulating water homeostasis.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center