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FEBS Lett. 2010 Jul 2;584(13):2883-90. doi: 10.1016/j.febslet.2010.05.004. Epub 2010 May 11.

Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6).

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Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.


Adenylyl cyclase (AC) type VI (AC6) is a calcium-inhibitable enzyme which produces cAMP upon stimulation. Herein, we characterized the specific role of AC6 in the kidneys using two AC6-knockout mouse lines. Immunohistochemical staining revealed that AC6 exists in the tubular parts of the nephron and collecting duct. Activities of AC evoked by forskolin or a selective agonist of the V2 vasopressin receptor were lower in the kidneys of AC6-null mice compared to those of wildtype mice. Results of a metabolic cage assay and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) showed for the first time that AC6 plays a critical role in regulating water homeostasis.

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