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BJOG. 2010 Jul;117(8):1005-10. doi: 10.1111/j.1471-0528.2010.02575.x. Epub 2010 May 11.

Effect of Swedish snuff (snus) on preterm birth.

Author information

1
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden. anna-karin.wikstrom@kbh.uu.se

Abstract

OBJECTIVE:

To compare the effects of Swedish snuff and cigarette smoking on risks of preterm birth.

DESIGN:

Population-based cohort study.

SETTING:

Sweden.

POPULATION:

All live, singleton births in Sweden 1999-2006.

METHODS:

Odds ratios (OR) with 95% confidence intervals (CI) were used to estimate relative risks for preterm birth in snuff users (n = 7607), light smokers (1-9 cigarettes/day; n = 41 436) and heavy smokers (ten or more cigarettes/day; n = 16 951) using non-tobacco users (n = 503 957) as reference.

MAIN OUTCOME MEASURES:

Very (<32 weeks) and moderately (32-36 weeks) preterm birth.

RESULTS:

Compared with non-tobacco users, snuff users had increased risks of both very (adjusted OR 1.38; 95% CI 1.04-1.83) and moderately (adjusted OR 1.25; 95% CI 1.12-1.40) preterm birth. Compared with non-tobacco users, light smokers had increased risks of both very (adjusted OR 1.60; 95% CI 1.42-1.81) and moderately (adjusted OR: 1.18; 95% CI: 1.12-1.24) preterm birth, and heavy smokers had even higher risks. Among smokers, but not among snuff users, the risk was more pronounced for spontaneous than induced preterm birth.

CONCLUSIONS:

The use of Swedish snuff was associated with increased risks of very and moderately preterm birth with both spontaneous and induced onsets. Swedish snuff is not a safe alternative to cigarette smoking during pregnancy.

[Indexed for MEDLINE]
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