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Ann Med. 2010 Jul;42(5):352-9. doi: 10.3109/07853890.2010.481678.

Co-occurrence of allergic sensitization and type 1 diabetes.

Author information

1
Department of Virology, University of Tampere, Tampere, Finland. tapio.seiskari@uta.fi

Abstract

BACKGROUND:

The mechanisms leading to abnormal immune regulation in type 1 diabetes and allergic diseases may be partly overlapping. If so, these diseases should co-occur more often than expected. We investigated this phenomenon in two contrasting socio-economic environments, Finland and Russian Karelia.

METHODS:

We screened 413 Finnish children (of whom 147 had type 1 diabetes) and 244 Russian Karelian children (132 had type 1 diabetes) for total immunoglobulin E (IgE) levels and specific IgE against birch, cat, and egg albumen. In addition we analysed diabetes-related human leukocyte antigen (HLA) haplotypes and antibodies against hepatitis A virus (HAV) and recorded allergic diseases by a questionnaire in Russian Karelia.

RESULTS:

In Russian Karelia 15% of the patients with type 1 diabetes, but only 4% of the control subjects had allergen-specific IgE (P = 0.012). A similar difference was observed in the frequency of allergic symptoms. Co-occurrence of allergic sensitization and type 1 diabetes was associated with lack of HAV antibodies and was not seen in Finland where infections are less frequent than in Karelia.

CONCLUSION:

Our findings support the idea of common mechanisms in the pathogenesis of allergic diseases and type 1 diabetes, which may be particularly important in an environment with low penetrance of these diseases.

PMID:
20465355
DOI:
10.3109/07853890.2010.481678
[Indexed for MEDLINE]

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