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Curr Diab Rep. 2010 Aug;10(4):276-82. doi: 10.1007/s11892-010-0120-8.

DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history.

Author information

1
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. rpbusui@umich.edu

Abstract

The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.

PMID:
20464532
PMCID:
PMC3608672
DOI:
10.1007/s11892-010-0120-8
[Indexed for MEDLINE]
Free PMC Article

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