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Int J Nanomedicine. 2010 Apr 7;5:137-45.

Atomic force microscopy probing in the measurement of cell mechanics.

Author information

1
Department of Physics, Laboratory for Thin Films-Nanosystems and Nanometrology, Aristotle University, Thessaloniki, Greece. dkirmizi@physics.auth.gr

Abstract

Atomic force microscope (AFM) has been used incrementally over the last decade in cell biology. Beyond its usefulness in high resolution imaging, AFM also has unique capabilities for probing the viscoelastic properties of living cells in culture and, even more, mapping the spatial distribution of cell mechanical properties, providing thus an indirect indicator of the structure and function of the underlying cytoskeleton and cell organelles. AFM measurements have boosted our understanding of cell mechanics in normal and diseased states and provide future potential in the study of disease pathophysiology and in the establishment of novel diagnostic and treatment options.

KEYWORDS:

atomic force microscopy; cell elastography; cell force spectroscopy; cell mechanics

PMID:
20463929
PMCID:
PMC2865008
DOI:
10.2147/ijn.s5787
[Indexed for MEDLINE]
Free PMC Article

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