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Blood. 2010 Sep 2;116(9):1397-404. doi: 10.1182/blood-2010-03-258608. Epub 2010 May 12.

Kidney disease associated with plasma cell dyscrasias.

Author information

1
Massachusetts General Hospital, Boston, 02114, USA. eheher@partners.org

Abstract

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

PMID:
20462963
PMCID:
PMC3324369
DOI:
10.1182/blood-2010-03-258608
[Indexed for MEDLINE]
Free PMC Article
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