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Breast Cancer Res. 2010;12(2):305. doi: 10.1186/bcr2563. Epub 2010 Apr 28.

Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression?

Author information

1
Dept. of Oncological Sciences, Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin, Italy. sara.cabodi@unito.it

Abstract

Two recent studies show that epigenetics and inflammation play a relevant role in the regulation of transformation and cancer cell self-renewal in breast tumours, opening up the possibility that cancer progression can be controlled by interfering with inflammation cascades. Struhl's group showed that transient activation of the Src oncoprotein induces transformation and self-renewal of immortal cells via an epigenetic switch involving NF-kappaB, Lin28, Let-7 microRNA and IL-6. Concomitantly, Wicha's laboratory developed a strategy to selectively target cancer stem cells, retarding tumour growth and reducing metastasis by blocking the IL-8 receptor CXCR1 using either an inhibitor, repertaxin or a specific blocking antibody.

PMID:
20459595
PMCID:
PMC2879570
DOI:
10.1186/bcr2563
[Indexed for MEDLINE]
Free PMC Article

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