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Tijdschr Psychiatr. 2010;52(5):287-98.

[The influence of cannabis on the course of bipolar disorder: a longitudinal analysis].

[Article in Dutch]

Author information

1
Lilly Nederland B.V., Houten. winter_van_rossum_inge@lilly.com

Abstract

BACKGROUND:

Research shows that the use of cannabis has a negative impact on the onset and outcome of schizophrenia, but little is known about possible effects on mood disorders.

AIM:

To study the influence of cannabis use on clinical and social treatment outcomes in patients with bipolar disorders who had been treated for a period of 12 months.

METHOD:

3459 bipolar patients were enrolled in an observational study. The influence of cannabis on various clinical and social treatment outcomes was examined over a period of one year. In addition, tests were applied in order to find out whether third, mediating variables had effects on possible associations between cannabis use and treatment outcomes.

RESULTS:

During 12 months of treatment cannabis users showed less compliance and higher levels of illness severity, mania and psychosis than did non-users. In addition, cannabis users were less satisfied with their lives and had less chance of forming relationships than non-users. There was little evidence that associations between cannabis use and treatment outcomes were mediated by third variables.

CONCLUSION:

Cannabis use clearly had an independent impact on clinical treatment outcomes in patients with bipolar disorder, but the impact on social outcomes was only modest.

PMID:
20458676
[Indexed for MEDLINE]
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