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Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7.

The nuclear factor NF-kappaB pathway in inflammation.

Author information

1
Inflammation Biology Group, Centre d'Immunologie Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille, France. lawrence@ciml.univ-mrs.fr

Abstract

The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.

PMID:
20457564
PMCID:
PMC2882124
DOI:
10.1101/cshperspect.a001651
[Indexed for MEDLINE]
Free PMC Article

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