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Bioorg Med Chem Lett. 2010 Jun 1;20(11):3295-300. doi: 10.1016/j.bmcl.2010.04.045. Epub 2010 Apr 18.

In vitro studies on a class of quinoline containing histamine H3 antagonists.

Author information

1
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6123, USA. huaqing.liu@abbott.com

Abstract

A series of quinoline containing histamine H(3) antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring.

PMID:
20457525
DOI:
10.1016/j.bmcl.2010.04.045
[Indexed for MEDLINE]

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