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Expert Rev Anti Infect Ther. 2010 May;8(5):589-606. doi: 10.1586/eri.10.36.

Intermittent preventive treatment against malaria: an update.

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Department of Tropical and Infectious Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.


Intermittent preventive treatment (IPT) against malaria is a malaria control strategy aimed at reducing the burden of malaria in certain high-risk groups, namely pregnant women and children. Three strategies - IPT in pregnancy (IPTp), infants (IPTi) and children (IPTc) - are reviewed here focusing on the mechanism of action, choice of drugs available, controversies and future research. Drugs for IPT need to be co-formulated, long acting, safe and preferably administered as a single dose. There is no obvious replacement for sulfadoxine-pyrimethamine, the most commonly utilized drug combination. All strategies face similar problems of rising drug resistance, falling malaria transmission and a policy shift from controlling disease to malaria elimination and eradication. IPT is an accepted form of malaria control, but to date only IPTp has been adopted as policy.

[Indexed for MEDLINE]

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