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J Oncol. 2010;2010:701476. doi: 10.1155/2010/701476. Epub 2010 Apr 29.

Intrahepatic sarcomatoid cholangiocarcinoma.

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Department of Histopathology, Nottingham University Hospitals, Queens Medical Centre Campus, University of Nottingham, NG7 2UH Nottingham, UK.


Intrahepatic sarcomatoid cholangiocarcinoma is a rare but an aggressive variant of cholangiocarcinoma with a very poor prognosis. We report the first caucasian patient who presented with a rapidly enlarging liver mass requiring hepatic resection. Detailed histopathological analyses including immunohistochemistry and electron microscopy confirmed sarcomatoid cholangiocarcinoma. The patient had early onset disease recurrence within 5 weeks of surgery. Here we demonstrate that combination chemotherapy with gemcitabine and cisplatin is a potential treatment option in patients with advanced sarcomatous cholangiocarcinoma. The patient achieved sustained partial remission with combination chemotherapy and remains alive and well more than 29 months since initial surgery.

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