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Biochem Cell Biol. 2010 Apr;88(2):359-69. doi: 10.1139/o09-187.

Charge, hydrophobicity, and confined water: putting past simulations into a simple theoretical framework.

Author information

1
Department of Physics, Stanford University, Stanford, CA 94305, USA. jengland@princeton.edu

Abstract

Water permeates all life, and mediates forces that are essential to the process of macromolecular self-assembly. Predicting these forces in a given biological context is challenging, since water organizes itself differently next to charged and hydrophobic surfaces, both of which are typically at play on the nanoscale in vivo. In this work, we present a simple statistical mechanical model for the forces water mediates between different confining surfaces, and demonstrate that the model qualitatively unifies a wide range of phenomena known in the simulation literature, including several cases of protein folding under confinement.

PMID:
20453936
PMCID:
PMC5328680
DOI:
10.1139/o09-187
[Indexed for MEDLINE]
Free PMC Article
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