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Nat Chem Biol. 2010 Jun;6(6):464-70. doi: 10.1038/nchembio.369. Epub 2010 May 9.

Reprogramming bacteria to seek and destroy an herbicide.

Author information

1
Department of Chemistry and Center for Fundamental and Applied Molecular Evolution, Emory University, Atlanta, Georgia, USA.

Abstract

A major goal of synthetic biology is to reprogram cells to perform complex tasks. Here we show how a combination of in vitro and in vivo selection rapidly identifies a synthetic riboswitch that activates protein translation in response to the herbicide atrazine. We further demonstrate that this riboswitch can reprogram bacteria to migrate in the presence of atrazine. Finally, we show that incorporating a gene from an atrazine catabolic pathway allows these cells to seek and destroy atrazine.

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PMID:
20453864
PMCID:
PMC2873063
DOI:
10.1038/nchembio.369
[Indexed for MEDLINE]
Free PMC Article

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