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Nat Cell Biol. 2010 Jun;12(6):522-4. doi: 10.1038/ncb2066. Epub 2010 May 9.

alpha-catenin mechanosensing for adherens junctions.

Author information

1
Thomas Lecuit is in IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy, Case 907. 13288 Marseille Cedex 09, France. lecuit@ibdml.univ-mrs.fr

Abstract

The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.

PMID:
20453846
DOI:
10.1038/ncb2066
[Indexed for MEDLINE]

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