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Spine (Phila Pa 1976). 2010 Aug 1;35(17):1602-6. doi: 10.1097/BRS.0b013e3181c7d28a.

Concordance for curve type in familial idiopathic scoliosis: a survey of one hundred families.

Author information

1
Department of Pediatric Orthopaedic Surgery, Hôpital des Enfants, Toulouse, France.

Abstract

STUDY DESIGN:

Prospective comparative study on 100 patients with positive family history for idiopathic scoliosis.

OBJECTIVE:

To evaluate the concordance rate for curve pattern and side in family members with idiopathic scoliosis.

SUMMARY OF BACKGROUND DATA:

The pathogenesis of idiopathic scoliosis has been the subject of extensive research. It is termed multifactorial with a genetic component. Similar curve shape has been reported in twins with idiopathic scoliosis.

METHODS:

We included prospectively 100 patients with idiopathic scoliosis when a relative of them was also affected with idiopathic scoliosis, and spine radiographs were available for both. Concordance for curve pattern by Lenke classification and side between family members was analyzed.

RESULTS:

Familial concordance rate for curve pattern and side was 66% (95% confidence interval, 57-75), whereas the expected random concordance rate was 26% (95% confidence interval, 17-34). The affected relative was in 27 cases a sibling, in 32 cases a parent, in 1 case an uncle, in 2 cases a cousin, in 2 cases a half sister, in 2 cases a grandmother. Concordance rate was 65% (27/42) in siblings' pairs and 67% (32/48) in parents/child's pairs.

CONCLUSION:

We report a high concordance rate for curve pattern and side between relatives with idiopathic scoliosis. Curve shape is likely to be genetically determined in familial scoliosis. It seems important that curve type is documented and considered in future genetic studies.

PMID:
20453726
DOI:
10.1097/BRS.0b013e3181c7d28a
[Indexed for MEDLINE]

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