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Trends Cell Biol. 2010 Jul;20(7):410-7. doi: 10.1016/j.tcb.2010.04.005. Epub 2010 May 7.

Yorkie: the final destination of Hippo signaling.

Author information

1
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.

Abstract

The Hippo signaling pathway is a key regulator of growth during animal development, whereas loss of normal Hippo pathway activity is associated with a wide range of cancers. Hippo signaling represses growth by inhibiting the activity of a transcriptional co-activator protein, known as Yorkie in Drosophila and Yap in vertebrates. In the 5 years since the first report linking Yorkie to Hippo signaling, intense interest in this pathway has led to rapid increases in our understanding of the action and regulation of Yorkie/Yap, which we review here. These studies have also emphasized the complexity of Yorkie/Yap regulation, including multiple, distinct mechanisms for repressing its transcriptional activity, and multiple DNA-binding partner proteins that can direct Yorkie to distinct downstream target genes.

PMID:
20452772
PMCID:
PMC2919348
DOI:
10.1016/j.tcb.2010.04.005
[Indexed for MEDLINE]
Free PMC Article

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