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Eur Neuropsychopharmacol. 2010 Sep;20(9):663-70. doi: 10.1016/j.euroneuro.2010.04.001. Epub 2010 May 8.

Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.

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1
Laboratory of Molecular Genetics, Department of Neurosciences B.B. Brodie, University of Cagliari, Cagliari, Italy. mirkomanchia@unica.it

Abstract

Bipolar Disorder (BPD) is a complex psychiatric disease with a relevant underlying genetic basis. HTR2A T102C, HTR2C Cys23Ser, SLC6A4 5-HTTLPR and rs25531 polymorphisms were genotyped in 230 BPD patients and inserted as covariates in a mixture regression model of age at onset (AAO). 5-HTTLPR polymorphism associated with early onset component under recessive and additive model. HTR2A T102C, HTR2C Cys23Ser and 5-HTTLPR interaction terms associated with early onset component under dominant, recessive and additive model. These findings suggest a role of genes codifying for elements of the serotonergic system in influencing the AAO in BPD.

PMID:
20452754
DOI:
10.1016/j.euroneuro.2010.04.001
[Indexed for MEDLINE]
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