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J Neuroimmunol. 2010 Jun;223(1-2):20-30. doi: 10.1016/j.jneuroim.2010.03.011. Epub 2010 May 8.

Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma + vaccination model.

Author information

1
Department of Neurosurgery, Virginia Commonwealth, Richmond, VA 23298-0631, USA.

Abstract

In rats bearing an intracranial T9 glioma, immunization with tumor antigens induces myeloid suppressor cells, which express neutrophil (His48) and monocyte (CD11bc) markers, to infiltrate the tumors. The His48(+)/CD11bc(+) cells were not derived from CNS microglia but were hematogenous; suppressed multiple T cell effector functions; and are myeloid-derived suppressor cells (MDSC). The glioma-infiltrating MDSC expressed arginase I, iNOS, indoleamine 2,3-dioxygenase and TGF-beta; however, inhibitor/blocking studies demonstrated that NO production was the primary mechanism of suppression which induced T cell apoptosis. These findings suggest that neuro-immunomodulation by MDSC in rat gliomas maybe mediated by a pathway requiring NO production.

PMID:
20452681
PMCID:
PMC2883008
DOI:
10.1016/j.jneuroim.2010.03.011
[Indexed for MEDLINE]
Free PMC Article

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