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Trends Microbiol. 2010 Jun;18(6):248-57. doi: 10.1016/j.tim.2010.04.001. Epub 2010 May 6.

NF-kappaB signaling modulation by EBV and KSHV.

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Department of Pathology, Botucatu School of Medicine, Sao Paulo State University (UNESP), Rubiao Junior, s/n - Botucatu, SP 18618-000, Brazil.


The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.

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