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Bioorg Med Chem Lett. 2010 Jun 1;20(11):3376-9. doi: 10.1016/j.bmcl.2010.04.019. Epub 2010 Apr 13.

Glycine amides as PPARalpha agonists.

Author information

1
Department of Medicinal Chemistry, Bayer Healthcare, Bayer-Schering Pharma, D-42096 Wuppertal, Germany. Klaus.Urbahns@astrazeneca.com

Abstract

The design, synthesis and pharmacological properties of a novel class of PPARalpha agonists is described. Compound 2 is a novel, potent and specific glycine amide with oral bioavailability in rodents. The compound is active in vivo and alters plasma lipids in hAPO-A1 transgenic mice after oral administration.

PMID:
20452212
DOI:
10.1016/j.bmcl.2010.04.019
[Indexed for MEDLINE]

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