Format

Send to

Choose Destination
Neuroimage. 2010 Oct 15;53(1):119-31. doi: 10.1016/j.neuroimage.2010.02.084. Epub 2010 May 5.

Multi-site characterization of an fMRI working memory paradigm: reliability of activation indices.

Author information

1
Athinoula A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Dept. of Radiology, Harvard Medical School, USA. ayendiki@nmr.mgh.harvard.edu

Abstract

Neuroimaging studies are facilitated significantly when it is possible to recruit subjects and acquire data at multiple sites. However, the use of different scanners and acquisition protocols is a potential source of variability in multi-site data. In this work we present a multi-site study of the reliability of fMRI activation indices, where 10 healthy volunteers were scanned at 4 different sites while performing a working memory paradigm. Our results indicate that, even with different scanner manufacturers and field strengths, activation variability due to site differences is small compared to variability due to subject differences in this cognitive task, provided we choose an appropriate activation measure.

PMID:
20451631
PMCID:
PMC3810293
DOI:
10.1016/j.neuroimage.2010.02.084
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center