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Clin Radiol. 2010 Jun;65(6):431-9. doi: 10.1016/j.crad.2010.03.001.

Imaging manifestations of progressive multifocal leukoencephalopathy.

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1
Division of Neuroradiology, Department of Diagnostic Radiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of JC virus in immunosuppressed patients. The diagnosis is usually suggested on imaging and confirmed by cerebrospinal fluid polymerase chain reaction (PCR) for JC virus DNA. In this article, we review the imaging manifestations of PML on computed tomography (CT), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), MR spectroscopy, single photon-emission computed tomography (SPECT) and positron-emission tomography (PET), and outline the role of imaging in follow-up and prognostication.

PMID:
20451009
DOI:
10.1016/j.crad.2010.03.001
[Indexed for MEDLINE]
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