Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

Aurelia Tubaro; Anna Giangaspero; Silvio Sosa; Roberto Negri; Gianpaolo Grassi; Salvatore Casano; Roberto Della Loggia; Giovanni Appendino

doi:10.1016/j.fitote.2010.04.009

Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins

Fitoterapia. 2010 Oct;81(7):816-9. doi: 10.1016/j.fitote.2010.04.009. Epub 2010 May 5.

Authors

Aurelia Tubaro¹, Anna Giangaspero, Silvio Sosa, Roberto Negri, Gianpaolo Grassi, Salvatore Casano, Roberto Della Loggia, Giovanni Appendino

Affiliation

¹ Dipartimento dei Materiali e delle Risorse Naturali, Università di Trieste, Via A. Valerio 6, 34127 Trieste, Italy. tubaro@units.it

PMID: 20450962
DOI: 10.1016/j.fitote.2010.04.009

Abstract

A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

Publication types

Comparative Study

MeSH terms

Administration, Topical
Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use*
Cannabinoids / isolation & purification
Cannabinoids / pharmacology
Cannabinoids / therapeutic use*
Cannabis / chemistry*
Croton Oil
Dermatitis / drug therapy*
Dermatitis / etiology
Ear
Inflorescence
Mice
Phytotherapy*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Skin / drug effects
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents
Cannabinoids
Plant Extracts
Croton Oil