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Vaccine. 2010 Jun 17;28(27):4356-61. doi: 10.1016/j.vaccine.2010.04.060. Epub 2010 May 4.

Frequent failure of adolescent booster responses to tetanus toxoid despite infant immunization: waning of infancy-induced immune memory?

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1
Department of Pediatrics, University Hospitals of Geneva, Switzerland.

Abstract

To define the capacity of a tetanus toxoid booster to reactivate infant-triggered immunity, anti-tetanus antibodies were assessed before and after boosting 162 adolescents and 219 children from Mfou (Cameroon). Among 63 adolescents with 3 recorded dose of infant DTP, 29/63 (46%) responded with a > or =4-fold increase of antibody titers, 35/63 (55%) reaching the 0.10UI/ml threshold. Response rates were slightly higher (62%) in children aged 10-11 years. Responders and non-responders only differed significantly in their baseline anti-tetanus antibodies. Thus, early life immune immaturity may limit the persistence of infant-induced immunity and subsequent boosters may be required for sustained protection.

PMID:
20447475
DOI:
10.1016/j.vaccine.2010.04.060
[Indexed for MEDLINE]
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