Format

Send to

Choose Destination
FEBS Lett. 2010 Jul 2;584(13):2845-51. doi: 10.1016/j.febslet.2010.04.068. Epub 2010 May 4.

The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.

Author information

1
University Lille Nord de France, Lille, France.

Abstract

Farnesoid X receptor (FXR) is highly expressed in liver and intestine where it controls bile acid (BA), lipid and glucose homeostasis. Here we show that FXR is expressed and functional, as assessed by target gene expression analysis, in human islets and beta-cell lines. FXR is predominantly cytosolic-localized in the islets of lean mice, but nuclear in obese mice. Compared to FXR+/+ mice, FXR-/- mice display a normal architecture and beta-cell mass but the expression of certain islet-specific genes is altered. Moreover, glucose-stimulated insulin secretion (GSIS) is impaired in the islets of FXR-/- mice. Finally, FXR activation protects human islets from lipotoxicity and ameliorates their secretory index.

PMID:
20447400
DOI:
10.1016/j.febslet.2010.04.068
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center