Format

Send to

Choose Destination
See comment in PubMed Commons below
Osteoporos Int. 2011 Jan;22(1):217-21. doi: 10.1007/s00198-010-1237-y. Epub 2010 May 6.

Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men.

Author information

1
General Clinical Research Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032, USA.

Abstract

We evaluated the effect of BMD on fracture risk prediction using FRAX® among Asian Indian men when used in conjunction with clinical risk factors. A majority of our subjects were either osteopenic or osteoporotic, and their fracture risk increased when FRAX® was used in conjunction with femur neck T-scores.

INTRODUCTION:

Asian Indian men living in the United States may represent a population that is at high and underappreciated risk for fragility bone fractures.

PURPOSE:

To evaluate the effect of BMD on fracture risk prediction using FRAX® among Asian Indian men when used in conjunction with clinical risk factors.

METHODS:

Forty four Asian Indian men (mean age 64.9 (±8.4) years) who had lived in the United States for an average of 33.6 (±10.6) years underwent BMD measurement at the proximal femur. Subjects were subjected to a general physical exam and history of fracture, hip fracture in a parent, current smoking and alcohol use, and diagnosis of inflammatory arthritis was obtained. Data from each subject were entered into the FRAX® algorithm and 10-year fracture probabilities were calculated using clinical risk factors (CRFs) alone and in combination with femur neck T-scores.

RESULTS:

Thirteen subjects (29.5%) had femur neck T-scores ≥ -1.0, 28 (63.6%) T-scores between -1.0 and -2.5, and three (6.8%) T-scores < -2.5. The 10-year probability of a major osteoporotic fracture based on a combination of clinical risk factors and femur neck T-scores was significantly higher than the fracture probability based on clinical risk factors alone (t(43) = 2.58, p = 0.01).

CONCLUSIONS:

Among Asian Indian men, the 10-year probability of a major osteoporotic fracture increases when femur neck T-scores are added to clinical risk factors in the FRAX® algorithm, and this population have a high fracture probability even in the absence of clinical risk factors.

PMID:
20445964
DOI:
10.1007/s00198-010-1237-y
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center