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J Invest Dermatol. 2010 Oct;130(10):2352-8. doi: 10.1038/jid.2010.119. Epub 2010 May 6.

p63 in skin development and ectodermal dysplasias.

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  • 1Department of Dermatology, Charles C. Gates Regenerative Medicine and Stem Cell Biology Program, University of Colorado Denver, Aurora, Colorado 80045, USA. Maranke.Koster@ucdenver.edu

Abstract

The transcription factor p63 is critically important for skin development and maintenance. Processes that require p63 include epidermal lineage commitment, epidermal differentiation, cell adhesion, and basement membrane formation. Not surprisingly, alterations in the p63 pathway underlie a subset of ectodermal dysplasias, developmental syndromes in which the skin and skin appendages do not develop normally. This review summarizes the current understanding of the role of p63 in normal development and ectodermal dysplasias.

PMID:
20445549
PMCID:
PMC2919658
DOI:
10.1038/jid.2010.119
[PubMed - indexed for MEDLINE]
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