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Nat Rev Mol Cell Biol. 2010 Jun;11(6):453-8. doi: 10.1038/nrm2905. Epub 2010 May 6.

Understanding eukaryotic chemotaxis: a pseudopod-centred view.

Author information

1
Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK r.insall@beatson.gla.ac.uk

Abstract

Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.

PMID:
20445546
DOI:
10.1038/nrm2905
[Indexed for MEDLINE]

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