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Clin J Sport Med. 2010 May;20(3):205-10. doi: 10.1097/JSM.0b013e3181df59f4.

Folic acid supplementation improves vascular function in amenorrheic runners.

Author information

1
Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

Abstract

OBJECTIVE:

The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners.

DESIGN:

Prospective cross-sectional study.

SETTING:

Academic medical center in the Midwest.

PARTICIPANTS:

Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study.

INTERVENTIONS:

Each participant was treated with folic acid (10 mg/d) for 4 weeks.

MAIN OUTCOME MEASURES:

Brachial artery FMD was measured before and after folic acid supplementation with standard techniques.

RESULTS:

The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52).

CONCLUSIONS:

This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.

PMID:
20445362
DOI:
10.1097/JSM.0b013e3181df59f4
[Indexed for MEDLINE]

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