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Eur J Pain. 2010 Oct;14(9):939-43. doi: 10.1016/j.ejpain.2010.03.002. Epub 2010 May 4.

Intrapartum and postpartum analgesia for women maintained on buprenorphine during pregnancy.

Author information

1
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Burlington, VT, USA. marjorie.meyer@uvm.edu

Abstract

OBJECTIVE:

To determine whether buprenorphine maintenance alters intrapartum or postpartum pain or medication requirements.

METHODS:

Sixty three patients treated with buprenorphine for opioid dependence during pregnancy (vaginal n = 44; cesarean n = 19) were matched retrospectively to control women. Analgesic medication and pain scores (0-10) were extracted from the medical record. Primary endpoint: opioid utilization postpartum (oxycodone equivalents). Secondary endpoints: pain scores and intrapartum analgesia.

RESULTS:

There were no differences in intrapartum pain or analgesia. Following vaginal birth, buprenorphine maintained women had increased pain (buprenorphine 2.7 (1.7,4.0); control 2.1 (1.2,3.0), p = 0.006) but no increase in opioid utilization (buprenorphine: 11.8 ± 24.8; control 5.4 ± 10.4 mg/24 h, p = 0.10); following cesarean delivery both pain (buprenorphine: 5.1 (4.1,6.1); control: 3.3 (2.5,4.1), p = 0.009) and opioid utilization (buprenorphine: 89.3 ± 38.0, control: 60.9 ± 13.1 mg/24 h, p = 0.004) were increased.

CONCLUSION:

Buprenorphine maintained women have similar intrapartum pain and analgesic needs during labor, but experience more postpartum pain and require 47% more opioid analgesic following cesarean delivery.

PMID:
20444630
DOI:
10.1016/j.ejpain.2010.03.002
[Indexed for MEDLINE]

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