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Cell Metab. 2010 May 5;11(5):341-2. doi: 10.1016/j.cmet.2010.04.010.

Lysosomal Rag-ulation of mTOR complex 1 activity.

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1
Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, 401 N. Middletown Road, Pearl River, NY 10965, USA.

Abstract

An amino acid-sensing pathway regulates mTOR complex 1 (mTORC1) activity and participates in nutrient control of cell metabolism and growth. Sancak et al. (2010) identify a lysosomal membrane-localized super-complex that drives amino acid-dependent mTORC1 activation.

PMID:
20444413
DOI:
10.1016/j.cmet.2010.04.010
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