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Mol Microbiol. 2010 May;76(4):822-32. doi: 10.1111/j.1365-2958.2010.07168.x. Epub 2010 Apr 25.

Macromolecules that prefer their membranes curvy.

Author information

1
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. kchuang@stanford.edu

Abstract

Understanding the mechanisms that underlie the organization of bacterial cells has become a significant challenge in the field of bacterial cytology. Of specific interest are early macromolecular sorting events that establish cellular non-uniformity and provide chemical landmarks for later localization events. In this review, we will examine specific examples of lipids and proteins that appear to exploit differences in membrane curvature to drive their localization to particular regions of a bacterial cell. We will also discuss the physical limits of curvature-mediated localization within bacteria, and the use of modelling to infer biophysical properties of curvature-sensing macromolecules.

PMID:
20444099
PMCID:
PMC2909655
DOI:
10.1111/j.1365-2958.2010.07168.x
[Indexed for MEDLINE]
Free PMC Article
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