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J Med Primatol. 2010 Oct;39(5):315-7. doi: 10.1111/j.1600-0684.2010.00411.x.

Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta).

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Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington DC, USA.



A 9-year-old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure.


Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells which infiltrated the myocardium and frequently exhibited intracytoplasmic luminae. Cells multifocally exhibited strong cytoplasmic immunoreactivity for Factor VIII-related protein (von Willebrand's factor).


The histological characteristics of this tumor are consistent with a diagnosis of epithelioid hemangioendothelioma, an intermediate-grade vasoformative neoplasm which has to our knowledge not previously been reported in the heart of a non-human species.

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