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Clin Transl Sci. 2009 Aug;2(4):312-4. doi: 10.1111/j.1752-8062.2009.00119.x.

Defining the components of the research pipeline.

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College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.


The National Institutes of Health (NIH) has proposed that research moves from "bench to bedside" through a Pipeline consisting of distinct research categories bridged by bidirectional translation. The original NIH Pipeline has now been expanded to include practice- and community-based research. We developed operational definitions for the elements along the expanded NIH Pipeline. The proposed definitions were pilot-tested and refined using the Computer Retrieval of Information on Scientific Projects (CRISP) and the Secure Internet-Linked Web Technologies (SILK) database containing funding information for individual NIH awards. Using our definitions, two reviewers independently agreed on the categorization of 94% of 866 National Heart, Lung, and Blood Institute (NHLBI)-funded projects, and 99% of projects could be placed into a single research category.

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